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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Curcumin
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“ Curcumin was more active than nicardipine in inhibiting LA and DHGLA conversion: 20 μM curcumin, alone or with simvastatin, totally inhibited Δ6 and Δ5 desaturation steps; 10 μM nicardipine only partially inhibited the enzymes, being more active on Δ5 desaturase.”
Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells“ Curcumin inhibited 97.3% lipid peroxidation of linoleic acid emulsion at 15 microg/mL concentration (20 mM).”
Antioxidant and radical scavenging properties of curcumin.“The present study has shown that 8.6 μM of curcumin bound to the PC micelles is required for 50% inhibition of linoleic acid peroxidation.”
“ Curcumin was the most active component and its 50% inhibitory concentrations for the air oxidation of linoleic acid were 1.83×10-2% (thiobarbituric acid value) and 1.15×10-2% (peroxide value).”
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