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Last Updated: 3 months ago

Possible Interaction: Curcumin and Iron, Dietary

supplement:

Iron, Dietary

Research Papers that Mention the Interaction

Curcumin reacted with iron in high concentrations at physiological pH at room temperature.
Clinical and experimental pharmacology & physiology  •  2018  |  View Paper
The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.
Bioinorganic chemistry and applications  •  2013  |  View Paper
Investigation of the physiological effects of iron binding by curcumin revealed that curcumin uptake by cultured cells was reduced >80% by addition of iron to the media; uptake was completely restored by desferoxamine.
We conclude that curcumin can selectively bind toxic metals including iron in a physiological setting, and propose inhibition of curcumin binding to iron-NTA-agarose for iron chelator screening.
BioMetals  •  2017  |  View Paper
Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron , and decreased the levels of dopamine and serotonin in the hippocampus.
Biological Trace Element Research  •  2014  |  View Paper
Taken together, these findings suggest that curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis.
Neuroscience Letters  •  2013  |  View Paper
Pathophysiological effects of iron were increased by saturated fat and decreased by curcumin.
The anti-oxidant curcumin reduced effects of iron on insulin signaling, ROS, and oxidative stress (p < 0.01).
Digestive Diseases and Sciences  •  2013  |  View Paper