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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Curcumin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Furthermore, in subsequent cell validation experiments, the results showed that curcumin caused marked accumulation of intracellular iron , reactive oxygen species, lipid peroxides, and malondialdehyde, while glutathione levels were significantly downregulated.”
Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells“ Curcumin reacted with iron in high concentrations at physiological pH at room temperature.”
“Investigation of the physiological effects of iron binding by curcumin revealed that curcumin uptake by cultured cells was reduced >80% by addition of iron to the media; uptake was completely restored by desferoxamine.”
“We conclude that curcumin can selectively bind toxic metals including iron in a physiological setting, and propose inhibition of curcumin binding to iron-NTA-agarose for iron chelator screening.”
Isolation and characterization of iron chelators from turmeric (Curcuma longa): selective metal binding by curcuminoids“Results Treatment of iron-overloaded rats with curcumin resulted in marked decreases in iron accumulation within liver and spleen.”
“Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron , and decreased the levels of dopamine and serotonin in the hippocampus.”
“Taken together, these findings suggest that curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis.”
“Pathophysiological effects of iron were increased by saturated fat and decreased by curcumin.”
“The anti-oxidant curcumin reduced effects of iron on insulin signaling, ROS, and oxidative stress (p < 0.01).”
“In in vitro experiments too curcumin inhibited iron catalyzed lipid peroxidation in liver homogenates, scavenged nitric oxide spontaneously generated from nitroprusside and inhibited heat induced hemolysis of rat erythrocytes.”
“Individually, both dietary curcumin and capsaicin significantly inhibited the in vivo iron‐induced LDL oxidation, as well as copper‐induced oxidation of LDL in vitro.”
“The treatment with Mn‐curcumin increased the Fe and Mn content in the kidneys of both control and Cd‐treated mice and Fe and Cu content in the brain of control mice.”
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