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Last Updated: 3 months ago

Possible Interaction: Curcumin and Homocysteine

supplement:

Homocysteine

Research Papers that Mention the Interaction

(3) ELISA showed IL-8 in the supernatant increased significantly in a time dependent manner after HCY treatment (P<0.01), but curcumin could significantly inhibit the IL-8 secretion in endothelial cells after HCY treatment.
(4) Western blotting showed HCY was able to markedly increase NF-κB expression, which, however, was significantly inhibited by curcumin.
American journal of translational research  •  2016  |  View Paper
Curcumin has antagonistic activity to homocysteine.
Postepy higieny i medycyny doswiadczalnej  •  2017  |  View Paper
Curcumin upregulated paraoxonase 1 (PON1) mRNA and caused significant increase in serum PON1 and homocysteine thiolactonase activities as compared to high ω-3 PUFA and ethanol group.
Oxidative medicine and cellular longevity  •  2016  |  View Paper
Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-κB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine , a known H(2) O(2) generator, on OC formation by restoring Gpx activity.
Journal of cellular biochemistry  •  2011  |  View Paper
Histopathological analysis also indicated that Hcy could decrease hippocampus cell count and Curcumin inhibited this toxic effect.
Pharmacology Biochemistry and Behavior  •  2010  |  View Paper
CONCLUSION These data demonstrate that curcumin effectively reverses the endothelial dysfunction induced by homocysteine.
Furthermore, superoxide anion levels of the endothelial layer were significantly increased by 2-fold in homocysteine-treated vessels as compared to control vessels (P = .02), whereas curcumin could block the effect of homocysteine on superoxide anion production.
More importantly, curcumin , a natural substance, can effectively block the detrimental effect of homocysteine on the vascular system.
Journal of vascular surgery  •  2004  |  View Paper