Possible Interaction: Curcumin and Homocysteine

“ Curcumin has antagonistic activity to homocysteine.”

“ Curcumin suppressed OC formation by increasing receptor activator of nuclear factor‐κB ligand (RANKL)‐induced glutathione peroxidase‐1, and reversed the stimulatory effect of homocysteine , a known H2O2 generator, on OC formation by restoring Gpx activity.”

“Histopathological analysis also indicated that Hcy could decrease hippocampus cell count and Curcumin inhibited this toxic effect.”

“CONCLUSION These data demonstrate that cu cumin ef fectively reverses the endothelial dysfunction induced by hom ocysteine. ”

“Furthermore, superoxide anion levels of the endothelial layer were significantly increased by 2-fold in homocysteine-treated vessels as compared to control vessels (P = .02), whereas curcumin could block the effect of homocysteine on superoxide anion production.”

“More importantly, curcumin , a natural substance, can effectively block the detrimental effect of homocysteine on the vascular system.”

“3) ELISA showed IL-8 in the supernatant increased significantly in a time dependent manner after HCY treatment (P<0.01), but curcumin could significantly inhibit the IL-8 secretion in endothelial cells after HCY treatment. (”

“4) Western blotting showed HCY was able to markedly increase NF-κB expression, which, however, was significantly inhibited by curcumin.”

“On the other hand Hcy could induce cell death and apoptosis in rats’ hippocampi which was inhibited by curcumin.”