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Last Updated: 3 months ago

Possible Interaction: Curcumin and Glutathione



Research Papers that Mention the Interaction

These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH , thus inhibiting HIF-1α stabilization to suppress CTGF expression to exhibit its protection on HCC.
Oxidative medicine and cellular longevity  •  2019  |  View Paper
Co-treatment with curcumin or α-tocopherol significantly attenuates depleted GSH , decrease in MDA and 8-OH-dG levels in propoxur exposed cells (p < 0.05).
Drug and chemical toxicology  •  2018  |  View Paper
However, the release of CCM was significantly accelerated in the presence of 10mM glutathione (GSH) at pH7.4 or pH5.5, in which 57% and 70% of CCM was released, respectively.
International journal of biological macromolecules  •  2018  |  View Paper
Curcumin pretreatment significantly attenuated ROS formation, inhibited the decreases of SOD activity and GSH level.
Toxicology mechanisms and methods  •  2015  |  View Paper
A plethora … that curcumin can bind and/or inhibit numerous targets including, for example, Nrf2, β-catenin, … nitric oxide synthase, nitric oxide, amyloid plaques, reactive oxygen species (ROS), cyclin D1, glutathione , cytosolic phospholipase A2, inhibitor of NF-κB kinase-1-…, p-Tau (p-τ) and tumor necrosis factor-α.
Cell Death and Disease  •  2015  |  View Paper
Therapeutical interventions that aim to increase GSH concentrations in vivo include N-acetyl cysteine; Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin , resveratrol, and cinnamon; and folate supplementation.
Molecular Neurobiology  •  2014  |  View Paper
Previously, we reported that curcumin induces reactive oxygen species (ROS)-mediated depletion of GSH , which leads to caspase-dependent and independent apoptosis in mouse fibroblast cells (F. Thayyullathil et al., Free Radic.
Taken together, our findings provide evidence suggesting for the first time that GSH regulates caspase-dependent inhibition of SMS activity, Cer generation, and apoptosis induced by curcumin in human leukemic cells.
Free radical biology & medicine  •  2012  |  View Paper
Curcumin pretreatment significantly attenuated these disturbances in intracellular ROS, liver enzyme activity and significantly antagonized the lipid peroxidation, GSH depletion and insulin resistance induced by GO in LO2 hepatocytes.
Hepato-gastroenterology  •  2011  |  View Paper
Exogenous GSH and its precursor N-acetyl-cysteine, but not ascorbic acid (AA) or ebselen, decreased curcumin accumulation in PC3 cells and also prevented curcumin-induced DNA fragmentation.
Nutrition and cancer  •  2010  |  View Paper
Curcuminoids also increased the islet content of glutathione (a product of the modulatory subunit of gamma-glutamyl-cysteine ligase) and the basal insulin secretion and protected them from oxidative stress.
Pancreas  •  2009  |  View Paper
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