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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“ Curcumin modulates relevant molecular target pathways to improve glucose and lipid metabolism, suppress inflammation, stimulate antioxidant enzymes, facilitate insulin signalling and reduce gut permeability.”
Curcumin, Cardiometabolic Health and Dementia“CONCLUSION Overall, cu cumin co nsumption was associated with a significant reduction in fas ting glucose, H OMA-IR, HbA1c, triglycerides and total cholesterol levels among patients with MetS and related disorders, but did not affect LDL- and HDL-cholesterol levels.”
“Furthermore, curcumin attenuated metabolic disorders via increasing concentration of glucose and fructose, and decreasing levels of glycine and proline, and mRNA expression of GLUT1, PKM and FASN.”
“We report that curcumin has an immediate inhibitory effect on basal glucose uptake in L929 fibroblast cells with a maximum inhibition of 80% achieved at 75 μM curcumin.”
“ Curcumin significantly attenuated the effect of HFD on glucose disposal , body weight/fat gain, as well as the development of insulin resistance.”
“Although the binding of glucose to curcumin reduces the cytotoxicity of the derivatives towards cisplatin (cDDP)-sensitive and -resistant human ovarian carcinoma cell lines, the compounds display a good selectivity since they are much less toxic against non-tumourigenic Vero cells.”
“ Curcumin … fasting glucose (mean difference (MD): −2.77, 95% confidence interval (CI): −4.16 to −1.38), fasting insulin (MD: −1.33, 95% CI: −2.18 …, 95% CI: −0.52 to −0.12), and quantitative insulin sensitivity check index (QUICKI) (MD: 0.010, 95% CI: 0.003–0.018).”
“ResultsHepatic fibrosis, serum cholesterol, glucose and alanin aminotransferase (ALT) reduced significantly only in curcumin group (p < 0.05).”
“At their respective MIC₉₀ values, in the presence of glucose , average inhibition of H+-efflux caused by CUR and MCD against standard, clinical and resistant isolates was 24%, 31%, 32% and 54%, 52%, 54%, respectively.”
“ Nanocurcumin significantly improved oxidative markers, glucose indices and TNF-α levels.”
Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-α modulations.
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