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Last Updated: 3 months ago

Possible Interaction: Curcumin and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

The treatment of a squamous cervical cancer cell line, SiHa, with 20 μM curcumin and genistein resulted in demethylation of promoter of the RARβ2 gene and led to the reactivation of the gene.
Folia biologica  •  2010  |  View Paper
These data suggest that the combination of curcumin and genistein in the diet have the potential to reduce the proliferation of estrogen-positive cells by mixtures of pesticides or 17-beta estradiol.
When curcumin and genistein were added together to MCF-7 cells, a synergistic effect resulting in a total inhibition of the induction of MCF-7 cells by the highly estrogenic activity of endosulfane/chlordane/DDT mixtures was noted.
Biochemical and biophysical research communications  •  1997  |  View Paper
Combining curcumin with high dose of genistein (50 μM) induced necrotic cells.
Whilst genistein alone at low concentration (≤10 μM) induced cell proliferation, addition of genistein (20 μM) 16 h after curcumin resulted in more cell death (89%), 34% higher than that administered at the same time (56%).
DARU Journal of Pharmaceutical Sciences  •  2012  |  View Paper
We found that genistein and curcumin showed additive effects on their potentiation of G551D-CFTR in high concentration range and also, more importantly, showed a significant synergistic effect in their minimum concentration ranges.
Current pharmaceutical design  •  2013  |  View Paper
CONCLUSIONS The additive effects between curcumin and genistein not only support the hypothesis that multiple mechanisms are involved in the action of CFTR potentiators, but also pose pharmaceutical implications in the development of drugs for CF pharmacotherapy.
CONCLUSIONS The additive effects between curcumin and genistein not only support the hypothesis that multiple mechanisms are involved in the action of CFTR potentiators, but also pose pharmaceutical implications in the development of drugs for CF pharmacotherapy.
However, curcumin further increased the channel activity of G551D-CFTR that had been already maximally potentiated by genistein , up to ~50% of the WT-CFTR level.
In addition, the combined application of genistein and curcumin over a lower concentration range synergistically rescued the gating defect of G551D-CFTR.
In addition, the combined application of genistein and curcumin over a lower concentration range synergistically rescued the gating defect of G551D-CFTR.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society  •  2011  |  View Paper