Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Curcumin and Epigallocatechin Gallate

Research Papers that Mention the Interaction

The encapsulation efficiency of curcumin in the core-shell nanoparticles was higher (96.2%) in the presence of EGCG than in its absence (77.9%).
Journal of agricultural and food chemistry  •  2019  |  View Paper
Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells.
The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin , whereas it was not changed by the treatment with each individual compound.
These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest.
BMB reports  •  2015  |  View Paper
Moreover, Cur and EGCG in combination could enhance the toxicity of DOX and increase the intracellular level of DOX in resistant MCF-7 cells.
Our present results showed that EGCG significantly enhanced the growth inhibition and apoptosis in both doxorubicin (DOX)-sensitive and resistant MCF-7 cells induced by Cur.
The American journal of Chinese medicine  •  2014  |  View Paper
Antibody against EGCG cell surface receptor, 67-kDa laminin receptor (67LR), was used to investigate the role of the receptor in curcumin’s increased potency by EGCG.ResultsIn this study, we showed that the combination of EGCG and curcumin significantly reduced SKN cell proliferation more than either drug alone.
EGCG enhanced the incorporation of curcumin.
International Journal of Clinical Oncology  •  2012  |  View Paper
Addition of Cis 4 h before Cur and EGCG (0/4 h combination) produced the most synergistic outcomes in both the A2780 and A2780(cisR) cell lines.
Anticancer research  •  2011  |  View Paper
CONCLUSIONS Curcumin treatment was able to overcome stromal protection of CLL B cells on in vitro testing and to synergize with EGCG when administered in a sequential fashion.
CONCLUSIONS Curcumin treatment was able to overcome stromal protection of CLL B cells on in vitro testing and to synergize with EGCG when administered in a sequential fashion.
When curcumin was administered simultaneously with EGCG , antagonism was observed for most patient samples.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2009  |  View Paper
Treatment of Apc mutant cells with low dose combination of select mechanistically … synthetic chemopreventive agents such as celecoxib (CLX) + difluoro methylornithine (DFMO), or naturally-occurring epigallocatechin gallate (EGCG) + curcumin (CUR) produced 160-400% and 220-430% decrease in the viable cell number respectively, relative to these agents used independently.
Oncology reports  •  2007  |  View Paper
Curcumin , for example, inhibits the differentiation-promoting activity of EGCG.
Biochemical pharmacology  •  2004  |  View Paper
We conclude that curcumin and EGCG produce opposing effects on involucrin gene expression via regulation of C/EBP factor function.
The Journal of biological chemistry  •  2004  |  View Paper
Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines.
Neural regeneration research  •  2018  |  View Paper
Show More