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Last Updated: 3 years ago

Possible Interaction: Curcumin and Epigallocatechin Gallate

Research Papers that Mention the Interaction

EGCG and CU combined treatment can improve the efficacy with synergistic effects.
ACS applied materials & interfaces  •  2019  |  View Paper
Studies in MDA‐MB‐231 cells demonstrated that EGCG + curcumin was synergistically cytotoxic and that this correlated with G2/M‐phase cell cycle arrest.
Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERα‐ breast cancer and that regulation of VEGFR‐1 may play a key role in this effect.
International journal of cancer  •  2008  |  View Paper
The encapsulation efficiency of curcumin in the core-shell nanoparticles was higher (96.2%) in the presence of EGCG than in its absence (77.9%).
Journal of agricultural and food chemistry  •  2019  |  View Paper
Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells.
The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin , whereas it was not changed by the treatment with each individual compound.
These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest. [
BMB reports  •  2015  |  View Paper
Moreover, Cur and EGCG in combination could enhance the toxicity of DOX and increase the intracellular level of DOX in resistant MCF-7 cells.
Our present results showed that EGCG significantly enhanced the growth inhibition and apoptosis in both doxorubicin (DOX)-sensitive and resistant MCF-7 cells induced by Cur.
The American journal of Chinese medicine  •  2014  |  View Paper
Antibody against EGCG cell surface receptor, 67-kDa laminin receptor (67LR), was used to investigate the role of the receptor in curcumin’s increased potency by EGCG.ResultsIn this study, we showed that the combination of EGCG and curcumin significantly reduced SKN cell proliferation more than either drug alone.
EGCG enhanced the incorporation of curcumin.
International Journal of Clinical Oncology  •  2012  |  View Paper
Addition of Cis 4 h before Cur and EGCG (0/4 h combination) produced the most synergistic outcomes in both the A2780 and A2780(cisR) cell lines.
Anticancer research  •  2011  |  View Paper
When curcumin was administered simultaneously with EGCG , antagonism was observed for most patient samples.
Clinical Cancer Research  •  2009  |  View Paper
Treatment of Apc mutant cells with low dose combination of select mechanistically … synthetic chemopreventive agents such as celecoxib (CLX) + difluoro methylornithine (DFMO), or naturally-occurring epigallocatechin gallate (EGCG) + curcumin (CUR) produced 160-400% and 220-430% decrease in the viable cell number respectively, relative to these agents used independently.
Oncology reports  •  2007  |  View Paper
Curcumin , for example, inhibits the differentiation-promoting activity of EGCG.
Biochemical pharmacology  •  2004  |  View Paper
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