Possible Interaction: Curcumin and Epigallocatechin Gallate

“ EGCG and CU combined treatment can improve the efficacy with synergistic effects.”

“Studies in MDA‐MB‐231 cells demonstrated that EGCG + curcumin was synergistically cytotoxic and that this correlated with G2/M‐phase cell cycle arrest.”

“Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERα‐ breast cancer and that regulation of VEGFR‐1 may play a key role in this effect.”

“The encapsulation efficiency of curcumin in the core-shell nanoparticles was higher (96.2%) in the presence of EGCG than in its absence (77.9%).”

“Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells.”

“The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin , whereas it was not changed by the treatment with each individual compound.”

“These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest. [”

“Moreover, Cur and EGCG in combination could enhance the toxicity of DOX and increase the intracellular level of DOX in resistant MCF-7 cells.”

“Our present results showed that EGCG significantly enhanced the growth inhibition and apoptosis in both doxorubicin (DOX)-sensitive and resistant MCF-7 cells induced by Cur.”

“Antibody against EGCG cell surface receptor, 67-kDa laminin receptor (67LR), was used to investigate the role of the receptor in curcumin’s increased potency by EGCG.ResultsIn this study, we showed that the combination of EGCG and curcumin significantly reduced SKN cell proliferation more than either drug alone.”

“ EGCG enhanced the incorporation of curcumin.”

“Addition of Cis 4 h before Cur and EGCG (0/4 h combination) produced the most synergistic outcomes in both the A2780 and A2780(cisR) cell lines.”

“When curcumin was administered simultaneously with EGCG , antagonism was observed for most patient samples.”

“Treatment of Apc mutant cells with low dose combination of select mechanistically … synthetic chemopreventive agents such as celecoxib (CLX) + difluoro methylornithine (DFMO), or naturally-occurring epigallocatechin gallate (EGCG) + curcumin (CUR) produced 160-400% and 220-430% decrease in the viable cell number respectively, relative to these agents used independently.”

“ Curcumin , for example, inhibits the differentiation-promoting activity of EGCG.”