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Last Updated: 3 months ago

Possible Interaction: Curcumin and Docosahexaenoic Acid

Research Papers that Mention the Interaction

Curcumin , diferuloyl methane found in the spice turmeric, has the potential to increase the formation of DHA from ALA by activating the enzymes FADS2 and elongase 2.
Therefore, supplementation of diets with ALA rich LSO and curcumin could increase DHA concentrations in serum, liver, heart and brain lipids which have implications for meeting the DHA requirements of vegetarian populations.
Prostaglandins, leukotrienes, and essential fatty acids  •  2017  |  View Paper
A synergistic effect was observed on induction of apoptosis (approximately sixfold) and inhibition of cell proliferation (approximately 70%) when cells were treated with curcumin (5 microM) together with the DHA (25 microM).
Nutrition and cancer  •  2008  |  View Paper
Intranasal DHA ME resulted in high brain concentrations and 10.76 (ABZ-SO) and 3.24 ( CUR ) fold enhancement in brain area-under-the-curve (AUC) compared to intravenous DHA MEs at the same dose.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V  •  2015  |  View Paper
ConclusionsThe SK-BR-3 cells and DMBA-induced tumors, both with an ER- and Her-2+ phenotype, were affected by the synergistic interaction of DHA and CCM.
ResultsAnalysis of gene microarray data indicates that combined treatment with DHA + CCM altered the profile of “PAM50” genes in the SK-BR-3 cell line from an ER-/Her-2+ to that resembling a “normal-like” phenotype.
The combination of DHA and CCM is potentially a dietary supplemental treatment for some breast cancers, likely dependent upon the molecular phenotype of the cancer.
BMC Cancer  •  2013  |  View Paper
All the combinations of CUR and DHA or EPA with lower concentrations of CUR 5 microM and 25 microM of DHA or EPA were found to have synergistic effects in suppressing LPS-stimulated NO and endogenous NO levels.
Biochemical pharmacology  •  2010  |  View Paper