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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Curcumin and Curcumin/ Demethoxycurcumin/Bisdemethoxycurcumin-Containing Supplement

Research Papers that Mention the Interaction

It has been reported that curcumin and dimc exerts differential cytotoxicity in normal and tumour cells and the reason for this had been attributed to the differential uptake of these compounds by normal cells and tumour cells.
Free radical research  •  2018  |  View Paper
Dimethoxycurcumin (DMC), one of several synthetic Cur analogues, has been reported to have increased metabolic stability over Cur.
Korean journal of urology  •  2010  |  View Paper
CONCLUSION The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at the same conditions.
RESULT The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin , the demi-period of curcumin prolonged with the addition of demethoxycurcumin.
Stability of curcumin is improved by demethoxycurcumin ,it is crude stabilizing agent.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials  •  2008  |  View Paper
The demethoxycurcumin is a nature stabilizing agent for curcumin.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2008  |  View Paper
However, treatment of the cells with Cur , DMC and BDMC exhibited a significant inhibition of cell invasion and motility with DMC and BDMC being more potent.
Archives of pharmacal research  •  2010  |  View Paper
Using a rat carotid arterial injury model, we show that DMC treatment was more potent than treatment with the other curcuminoids with respect to reducing intima/media ratios and the number of proliferating cells.
Molecular nutrition & food research  •  2013  |  View Paper
After 5 days of treatment, the curcuminoid mixture and demethoxycurcumin effectively decreased GFAP levels in the hippocampus.
Brain Research  •  2011  |  View Paper
Both DMC and Cur could markedly decrease iROS production and the expression of NADPH oxidase induced by LPS, with more potent inhibitory activity of DMC.
International immunopharmacology  •  2010  |  View Paper