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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Curcumin
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“ Curcumin treated with CYP 2D6, CYP1A1, or CYP1A2 induced DNA damage in the presence of Cu(II).”
Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.“Intracellular ROS was completely restored by adding Cu2+ , which can bind and modify the curcumin 's physico-chemical property, and this resulted in a marked potentiation of its anti-proliferative effect.”
“Low dosage of curcumin depressed oxidative stress levels exacerbated by Cu(II).”
“These results suggest that curcumin , in a concentration-dependent manner, plays both anti-oxidative and pro-oxidative roles in primary neurons treated with Cu(II).”
“When Cu(II) was presented in primary neurons, curcumin at high dosage resulted in chromosomal aberration and cell damage.”
Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II).“ Curcumin was found to be the most effective in the DNA cleavage reaction and a reducer of Cu(II ) followed by dmC and bdmC. The rate of formation of hydroxyl radicals by the three curcuminoids also showed a similar pattern.”
“We have earlier shown that curcumin in the presence of Cu(II) causes strand cleavage in DNA through generation of reactive oxygen species, particularly the hydroxyl radical.”
“In this paper we show that in the presence of Cu(II), curcumin caused breakage of calf thymus and supercoiled plasmid pBR322 DNA.”
“The ESA kinetics of the Cu(II)-curcumin complexes exhibit a sharp rise and a fast decay with a time constant of approximately 1 ps in both media due to the strong interaction between Cu(II) and curcumin.”
“The Cu(II) ion exhibits a high efficiency in quenching the fluorescence of curcumin.”
Femtosecond transient absorption spectroscopy of copper(II)-curcumin complexes.
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