Possible Interaction: Cupric Cation and Zinc Cation

“Common multivalent cations present in biological systems like Al3+, Cu2+ , Fe3+, Ca2+, and Mg2+, interfered with the measurement of Zn(II ) only when present in excess of 20, 33, 60, 500 and 30,000 times the Zn (II) concentration, respectively.”

“When aggregates are prepared in the copresence of Cu(II) and Zn(II) ions , the ratio of Cu(II):Zn(II) becomes an important factor in the degeneration of H2O2, the formation of carbonyl groups in the peptide, and in aggregate morphology.”

“20 times enhancement in fluorescence intensity on interaction with Zn2+ , due to snapping of photoinduced electron transfer (PET) process, which is selective over metal ions - Na+, K+, Ca2+, Ni2+, Cu2+ , Cd2+, Hg2+ and Pb2+.”

“From these studies, we suggest that Abeta-chelated Zn(II) is readily displaced by Cu(II) and Fe(III) ions and leads to a propagation of oxidative stress.”

“ Zn(II ) promoted L55P amyloid formation at pH 7.4 but Cu(II) inhibited it.”

“ Zn(II ) inhibited whilst Cu(II) prevented the formation of beta-pleated sheets of Abeta42and neither of these influences were affected by incubation of the aged peptide aggregates with either DFO or EDTA.”

“Plasma ceruloplasmin (added to the basal chamber) failed to enhance basolateral iron release, and Zn(II ) failed to compete with Cu(II ) for uptake.”

“Conclusion: Our results suggest that the Zn(II) and Cu(II) complexes display significant MDR-reversing activity in a dose-dependent manner and possess strong cytotoxic activity and a remarkable potential to induce apoptosis in MDR L5178Y mouse T-lymphoma cells.”

“Here we show that Zn(II) and Cu(II) inhibit Aβ42 fibrillization and initiate formation of non‐fibrillar Aβ42 aggregates, and that the inhibitory effect of Zn(II) (IC50 = 1.8 μmol/L) is three times stronger than that of Cu(II).”

“Transmural S to M transport of 65Zn2+ was markedly reduced with the addition of the serosal inhibitors ouabain (32%), excess K+ (25%), excess Ca2+ (30%), Cu2+ (38%), nifedipine (21%), and vanadate (53%).”