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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cupric Cation
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Previous studies have shown that both αA- and αB-crystallins bind Cu2+, suppress the formation of Cu2+-mediated active oxygen species, and protect ascorbic acid from oxidation by Cu2+.”
Identification and characterization of a copper-binding site in αA-crystallin.“A small amount of Cu(II) is reduced to Cu(I) by ascorbic acid , then Cu(I) is precipitated with SCN-.”
“ Ascorbic acid played the main role in the reduction of Cu(II) , whereas the contribution of superoxide anions was less significant.”
“We observed that AA is oxidized rapidly when incubated with Cu2+ and LDL, leading to transient formation of dehydro-L-ascorbic acid (DHA).”
“The addition of vitamin C (0.1-1 mM) to a solution of fibrinogen (1 mg/ml) and Cu(II) (20-150 microM) results in protein coming out of solution.”
“All of the three transition metal ions form complexes with vitamin C , but only in the case of Cu2+ and Fe3+ the interaction results in a reduction of the metal ions.”
“Synergic action of Cu(II) complexes with ascorbic acid against Candida albicans induced the generation of free radicals and increased (more than 60 times) antimicrobial effect of these complexes.”
“The inhibition by ascorbic acid is enhanced by cupric ions.”
“ Cupric ion catalytically enhances the autoxidation of L-ascorbic acid.”
Disulfide cleavage and insulin denaturation by active oxygen in the copper(II)/ascorbic acid system.“Nevertheless, the inhibitions of ATPases by Hg2+, Cu2+ and Zn2+ were decreased, unaltered and additively enhanced in combination with AA , respectively.”
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