Possible Interaction: Cupric Cation and Manganese Cation (2+)

“These results predict that increases in Cu(II) or Zn(II) levels may also increase the steady-state levels of Mn(II ) in the cytoplasmic fraction of glial cells, which may in turn alter the activity of Mn(II)-sensitive enzymes in this cell compartment.”

“Zn(II) inhibits but Cu(II) activates Mn(II) uptake.”

“The presence … or Mn(II ) enhanced the frequency of … peroxide (H2O2) and Cu(II) , and altered the site specificity of the latter: H2O2 induced Cu(II)‐dependent DNA damage with high frequency … poly G sequences; when SODs were added, the frequency of cleavages at thymine and cytosine residues increased.”

“ Cu(II) and Mn(II) (10(-4) or 10(-5) M) enhanced both actions.”

“At pH 7.7, dissolved Cu(II) accelerated Mn(II) oxidation more than 10 times with a dose of 20 μg/L. Solid characterization revealed that during Mn(II) oxidation, Cu(II) adsorbed to freshly formed MnOx and produced Mn-Cu mixtures (denoted as MnOx-Cu(II)).”

“Variable temperature magnetic susceptibility measurements suggest that all five complexes possess an overall antiferromagnetic interaction between Cu(II) and Mn(II) ions, which results in a final ferrimagnetic ground state with spin 3/2 in the Cu(II)-Mn(II)-Cu(II) trinuclear structure.”

“While the extracellular Mn(II)-oxidizing factor (MOF) is thought to be a putative multicopper oxidase, … in the presence of zero added Cu(II) was detected and the decrease in the observed Mn(II) oxidation rate in iron-limited cultures was … when the medium was supplemented with Cu(II).”

“EPR spectra of Mn(II) and Cu(II ) show considerable exchange interaction in the complex.”

“A synergistic effect of Cu(II) with a second metal ion (Ni(II), Co(II) or Mn(II) traces ) was observed.”

“Co(II), Ni(II), Zn(II), Fe(II), or Cu(II ) could compete with Mn(II ) during reconstitution of the apoenzyme.”