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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Cupric Cation
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“The enzyme had maximal activity in the presence of Mg2+ (40 muM) and Mg2+ (4 mM) stabilized the enzyme at 37 degrees C. Cupric ion (0.5 mM) inhibited (50%) enzyme activity in the presence or absence of Mg2+.”
Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia.“The result showed that Mg(II) has weaker binding capacity with the drug comparing Cu(II) , but both Mg(II) and Cu(II) can obviously reduce the binding constant of DNA with the drug.”
The influence of Cu(II), Mg(II) on the binding of adriamycin with DNA and the study on their interaction mechanism.“It was activated by Mg2+ ion and inhibited by Cu2+ and Zn2+.”
“Zn++, Ni++, Cu++ , Fe++, Sn++ and Hg++, in the presence of 5mM Mg++ , inhibited cAMP PDE activity whereas these divalent metal ions alone did not affect enzyme activity if Mg++ were absent.”
“It is established that Ca++ activates, and Fe++ has not effect on the activity of acid and alkaline DNases, while Mg++ , Mn++ and especially Co++, Zn++, Cd++, Cu++ have an inhibitory effect on them.”
“The presence of Mg2+ , Ca2+ and Ba2+ cations strongly activated the enzyme; however, Cu2+ and Zn2+ cations had inhibitory effects on the enzymatic activity.”
Hydrolysis of Fucoidan by Fucoidanase Isolated from the Marine Bacterium, Formosa algae“It was found that Cu++ enhanced the binding, but that Al+++, Ca++, Mg++ , Zn++, Mn++, Na+, and K+ did not.”
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