“On the other hand, if trypsin is introduced into the inflamed area 5 days after the croton oil , the granulomatous lining, formed under the influence of this chemical irritant, protects the adjacent tissues against otherwise toxic concentrations of this enzyme.”
“Summary Using the granuloma-pouch as an indicator, it has been shown that trypsin , given simultaneously with croton oil , causes particularly intense and widespread tissue-damage in the rat.”