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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cromolyn and Calcium Supplement

Research Papers that Mention the Interaction

These phosphorylations occur independently of NO binding and the direct inhibitory effect of calcium is observed for all the sCG forms.
Journal of cellular biochemistry  •  2002  |  View Paper
A mechanism of the action of DSCG , either against the contraction of ileal smooth muscle or against histamine release from mast cells, is discussed with a view to the inhibition of the utilization of calcium ions by both cells.
Agents and Actions  •  2005  |  View Paper
From the present results it is suggested that quercetin selectively and verapamil primarily act to block calcium-gate opening resulting from antigen-antibody interaction on the mast cell membrane, while theophylline and disodium cromoglycate selectively inhibit the passage of calcium through open calcium channels.
Agents and Actions  •  2005  |  View Paper
Some ofthe earliest studies investigating the mechanism of action of sodium cromoglycate showed that the compound inhibited the influx of calcium ions [1] and phosphorylated a 78 000 molecular weight (78 kDa) protein [2,3] in rat peritoneal mast cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology  •  1996  |  View Paper
Furthermore, DSCG inhibits 45Ca++ uptake by guinea pig ileum after acetylcholine stimulation which constitutes strong evidence that inhibition of calcium ion utilization by smooth muscle cells plays a major role in the mode of action of DSCG.
Allergologia et immunopathologia  •  1983  |  View Paper
It seems that quercetin selectively and verapamil primarily act to block calcium-gate opening resulting from antigen-antibody interaction on the mast cell membrane, while theophylline and DSCG selectively inhibit the passage of calcium through open calcium channels.
Acta medica Okayama  •  1981  |  View Paper
The specific degranulation inhibiting effect of DSCG is increased in the presence of Ca++ and Mg++ ions.
Arzneimittel-Forschung  •  1976  |  View Paper
The electrokinetic properties of intact rat mast cells are described; disodium cromoglycate caused a plasma membrane alteration possibly related to Ca 2 + influx.
Biochemical pharmacology  •  1976  |  View Paper
Thus, it is possible that one of the ways that DSCG inhibits is by preventing the increased uptake of calcium by cells under the influence of histamine release initiators such as compound 48/80 or antigen-antibody reactions, and thereby inhibiting mediator release.
Journal of immunology  •  1975  |  View Paper