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“In vivo, PGA significantly attenuated kidney injury and reduced blood urea nitrogen (BUN), serum creatinine (CREA) and urinary albumin (Alb), and increased creatinine clearance (CC) in IRI mice.”
“The results demonstrate (1) a spectrum …) a reduction in concentrating ability and creatinine … folic acid in the range of 100 to 300 mg/kg; and (3) increased mitotic activity at high doses …/kg) of all renal tubular cell types examined, with collecting ducts demonstrating the greatest degree of regeneration.”