Possible Interaction: Creatinine and Asymmetric Dimethylarginine

“In patients with UCAH, a pronounced positive correlation was found between the concentration of ADMA and creatinine level (r=0.615, p.”

“In our study, to eliminate such effects on ADMA, we have carefully chosen the study group from individuals who have normal urea, creatinine , SGOT, SGPT, hsCRP, cholesterol, triacylglycerol, systolic and diastolic blood pressure and body mass index, as these factors may increase ADMA levels.”

“Also in the whole examined population tHcy and creatinine concentration were significantly correlated with ADMA (β = 0.2598, P = 0.008 and β = 0.2452, P = 0.034, respectively).”

“Plasma homocysteine (tHcy) and creatinine concentrations were found to be significantly correlated with plasma ADMA concentration in the passive smokers group (Table 1).”

“Simultaneous plasma ADMA concentration was similar to that in healthy subjects while symmetric dimethyl-arginine (SDMA) levels were substantially increased and directly related with creatinine.”

“ ADMA and SDMA levels increased with the progression of renal dysfunction and were negatively related to creatinine clearance (Ccr) in pre-dialysis patients (r=-0.315, P<0.05; r=-0.426, P<0.01).”

“In addition, arterial SDMA concentration, but not ADMA concentration, significantly correlated with arterial creatinine concentration.”

“ ADMA associated positively (p < 0.05) with creatinine and 8-OHdG. In conclusion, vascular dysfunction was associated with obesity, high blood pressure, oxidative stress and microalbuminuria in South African children of African ancestry.”

“ Creatinine , albumin and ACR significantly (p < 0.005) increased with increasing ADMA.”