Possible Interaction: Creatine and Triiodothyronine

“… T3 … creatine compared with the placebo group, respectively, for body mass (1.86 and -1.01 kg), fat-free mass (2.22 and 0.00 kg), … (9-15 and -6 to 1%), lower-body mean power (11 and 0%), and lower-extremity functional capacity (6-9 and 1-2%).”

“We exposed myoblasts to triiodothyronine T3 ) in the presence of 0.5mM creatine simultaneously for 48 h. As Figure 3 shows, this increased cellular [creatine] by up to 200%.”

“Although the uptake of radioactive creatine of denervated muscles was significantly lower than that of controls, inhibitory action of T3 on creatine uptake was similarly observed in denervated muscles as well as in normal ones.”

“The results indicate that T3 has a direct effect on muscle cell per se and the inhibitory action of T3 on creatine uptake by the muscle is closely related to T3 action on the energy-requiring process in cell membrane.”

“The uptake of radioactive creatine of all muscles studied significantly diminished after T3 (100 microgram/100 g, s.c.)”

“ Creatine content in muscles decreased significantly 48 h after T3 injection.”

“ T3 increased the plasma creatine level both in bilateral nephrectomized and in bilateral nephrectomized plus beta-GPA administrated groups.”