Possible Interaction: Creatine and S-Adenosylmethionine

“However, creatine synthesis does account for approximately 40% of all of the labile methyl groups provided by S-adenosylmethionine (SAM) and, as such, places an appreciable burden on the provision of such methyl groups, either from the diet or via de novo methylneogenesis.”

“Unexpectedly, creatine supplementation decreased the concentrations of S-adenosylmethionine , while those of S-adenosylhomocysteine were not altered significantly.”