Possible Interaction: Creatine and Phosphoric Acid

“3 This is quite in accord with the current concept of the chemistry of muscular contraction wherein creatine in its combination with phosphoric acid plays an important role.”

“These observations … of the phosphoric acid exercising a controlling influence on … skeletal muscle to take up creatine , and in order to test this hypothesis the concentration of phosphoric acid and of creatine in … has been determined under certain experimental conditions which included the administration of creatine and of phosphates.”

“IT has been established that creatine forms an unstable compound with phosphoric acid in the voluntary muscles of vertebrates [Fiske and Subbarow, 1927; G. P. and P. Eggleton, 1927].”

“It seemed reasonable to suppose, therefore, that if creatine introduced into the body does enter into combination with phosphoric acid , the excretion of phosphates in the urine might be affected.”