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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Creatine
drug:
Phosphocreatine
Research Papers that Mention the Interaction
“ Creatine supplementation increased muscle total-Cr, free-Cr and phosphocreatine ( PCr ) content above placebo following 1, 3 and 6 days of supplementation (all P < 0.05).”
Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans“ Cr supplementation produced a 11.5 ± 4.6% increase in the resting muscle phosphocreatine (PCr) concentration and a 65.0 ± 4.2% increase in the PCr degradation during Ex10.”
“The results suggest that Cr supplementation enhanced PCr degradation during Ex10.”
“ Creatine loading significantly increased total creatine, free creatine and creatine phosphate content with a concomitant 18 +/- 5% increase in muscle glycogen content (P<0.05).”
“ Creatine uptake by the muscle fibers results in an elevation of intracellular phosphocreatine ( PCr ) levels because of the equilibrium reaction of creatine kinase.”
“ Phosphocreatine levels were also significantly higher (P < 0.05) immediately and 3 min after the completion of exercise in the Cr condition.”
“Force-time integrals (P =.03) and depletion of phosphocreatine (P =.04) increased significantly during ischemic exercise with creatine.”
“ Cr and Cr+C increased (P < 0.05) muscle PCr concentration by 4-6%.”
“The data show that Cr supplementation elevates muscle PCr concentration and markedly improves performance during intense intermittent exercise.”
“While no change was seen in the placebo group compared to baseline, creatine supplementation increased skeletal muscle total creatine and creatine phosphate by 17 +/- 4% (P < 0.05) and 12 +/- 4% (P < 0.05), respectively.”
“We found that these molecules increase levels of creatine after block of the transporter, and significantly increased the levels of phosphocreatine.”
“Administration of creatine increases the brain levels of creatine and phosphocreatine.”
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