Possible Interaction: Creatine and N-Acetylaspartate

“Analysis of the SE 135 ms spectra indicates there are statistically significant differences in the ratios of N-acetyl-aspartate to creatine and N-acetyl-aspartate to choline between controls and MND patients.”

“Nuclear magnetic resonance spectroscopy showed that creatine supplementation significantly increased brain creatine concentrations and delayed decreases in N-acetylaspartate concentrations.”

“The ratio of NAA and Cr was increased as compared with that before treatment (P<0.”

“In MRS, the ratio of N‐acetyl aspartate to creatine (NAA/Cr) was significantly decreased in the pons and both thalami.”

“The estimates for creatine , glutamate, and GABA showed significant linear correlations with those of NAA.”

“Variation in the cellular content of total creatine accounted for more than three-quarters of the rank-order variance of the N-acetyl-aspartate concentrations.”

“These data are compatible with the interpretation that creatine supplementation causes an increase in the diminished NAA levels in ALS motor cortex as well as an increase of choline levels in both ALS and control motor cortices.”

“Results: N-acetylaspartate NAA ) and creatine were reduced markedly in both groups of patients, particularly in the advanced group (approximately 60%), but the decrease was also significant in presymptomatic patients (approximately 30%) whose motor and cognitive performances were within the normal range.”

“We used 1H-magnetic resonance spectroscopy of the brain and found that the ratio of N-acetyl aspartate to creatine in AD patients was significantly smaller than that in age-matched controls without dementia.”

“NAA is located primarily within neurons, and reduction of the ratio of NAA to choline, creatine , and phosphocreatine is a marker of neu‐ronal loss and dysfunction.”