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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The mechanism whereby creatine potentiates insulin release is yet to be investigated.”
Effect of creatine on the pancreatic beta-cell.“ Insulin and insulin-stimulating foods appear to enhance muscle uptake of creatine but at the same time, high carbohydrate meals may slow the absorption of creatine from the intestine.”
“Second, the stimulatory effect of insulin on creatine disposal was diminished within the initial 24 h of supplementation.”
“These findings demonstrate that insulin can enhance muscle creatine accumulation in humans but only when present at physiologically high or supraphysiological concentrations.”
“ Creatine accumulation at 48 h was increased to 230 ± 6% of control by insulin and by 140 ± 13% by IGF-I (both at 3 nM).”
The regulation of total creatine content in a myoblast cell line“Plasma insulin was profoundly decreased to 20-25% of normal by the creatine analog treatment while plasma glucagon levels were increased.”
“This increase in total content of creatine , stimulated by insulin , was accompanied by rapid diappearance of inorganic phosphate, which was especially distinct within 1 min of inculation at 30 degrees.”
“The blood creatine concentration in rats treated with 2 units of insulin increased to 114% of the control value 1 hr after creatine loading and then decreased slightly after 2 hr.”
“The results indicate that 0.5–2.0 units of NPH insulin administered sc 2 hr prior to the injection of 5 mg of creatine prevented creatinuria induced by creatine loading.”
“These results show that the hyper-… occurs in rats shortly after creatine loading can also … suppressed by insulin , suggesting that the action of the hormone in preventing load-induced creatinuria is related to its … on the blood creatine concentration, rather than to an effect on the kidneys per se.”
“ Creatine supplementation has also been reported to trigger the skeletal muscle expression of insulin like growth factor I, to increase the fat-free mass and improve cognition in elderly, and more explorative approaches like transcriptomics has revealed additional information.”
Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics“These findings demonstrate that insulin can enhance muscle creatine accumulation in humans but only when present at physiologically high or supraphysiological concentrations.”
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