Possible Interaction: Creatine and Homocysteine

“These authors demonstrated that 42% of the vegan subjects studied presented HHcy (Hcy > 15 lmol/L); three weeks of creatine supplementation significantly (P < 0.05) reduced plasma Hcy concentration.”

“This is particularly relevant since creatine synthesis from Hcy as a subproduct and an elevated creatine synthesis demand may increase Hcy formation.”

“The formation of creatine from GAA consumes methyl groups, and increases production of homocysteine.”

“Urinary excretion of creatine was negatively correlated with plasma concentration of homocysteine.”

“ Creatine prevents some alterations caused by homocysteine.”

“Although creatine prevents some alterations caused by homocysteine , it should be used with caution, mainly in healthy individuals because it could change the homeostasis of normal physiological functions.”

“ Creatine , when combined with homocysteine , prevented or caused a synergistic effect on some changes provoked by this amino acid.”

“Nevertheless, creatine supplementation significant decreased (P < 0.05) homocysteine concentration independent of exercise intensity (AnCr group: pre 17%, 0 h 80%, 2 h 107%, and 6 h 48%; ACr group: pre 17%, 0 h 19%, 2 h 28%, and 6 h 27%).”

“On the other hand, creatine supplementation decreased plasma Hcy independent of exercise intensity.”

“In addition, Hcy showed significant negative correlation (P < 0·05) with plasma creatine (r − 0·61) and positive correlation with plasma TBARS (r 0·74).”

“Since creatine synthesis is responsible for most of the methyl group transfers that result in Hcy formation, creatine supplementation might inhibit Hcy production and reduce free radical formation.”

“We conclude that creatine supplementation reduces plasma Hcy levels and lipid peroxidation biomarkers, suggesting a protective role against oxidative damage.”