supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Creatine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“The ratio of GABA to Cr was significantly lower in the ASD group than the control subjects.”
Decreased left perisylvian GABA concentration in children with autism and unaffected siblings“In contrast, creatine was reduced significantly less then GABA (∼19% signal loss).”
“ Creatine uptake was inhibited by a 100-fold excess of various compounds with the following potency order: cold creatine = guanidinopropionic acid > nipecotic acid > gamma-aminobutyric acid (GABA) = beta-alanine = betaine, whereas carnitine, glycine, taurine, and choline were without effect.”
Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex.“ Creatine (25 mM) also diminished the release of [3H]GABA (expressed as dpm/mg wet weight) from rat neostriatal slices, probably by reducing its synthesis and thus its readily releasable pool.”
“Thus, indirect evidence was obtained that creatine decreased the activity of the synthesizing enzyme of GABA , i.e., glutamate decarboxylase.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback