Possible Interaction: Corticosterone and Vitamin E

“Prenatal exposure to vitamin E and corticosterone appears to have antagonistic effects on body growth, although vitamin E is not limiting in yellow-legged gull eggs.”

“Summary: Vitamin E and corticosterone apparently have antagonistic effects on body growth in yellow-legged gull embryos but vitamin E is not limiting.”

“The functional relationship between vitamin E and corticosterone is corroborated by the observation of positive covariation between these compounds.”

“We found that NAC and vitamin E induced an increase in plasma corticosterone levels.”

“As a conclusion, the protective effect of vitamin E was related to the ability to inhibit stress induced elevation of corticosterone and noradrenalin levels.”

“ Vitamin E significantly decreased corticosterone levels in all stress groups compared with their respective control groups.”

“In vivo experiments on animals have demonstrated that vi amin E de creases the toxicity of several com pounds, i ncluding nitrogen dioxide (Elsayed and Mustafa 1982), hydrazine (Antosiewicz et al. 1994a), and methyl ethyl ketone peroxide (MEKP) (Ando and Tappel 1985).”

“These findings indicate that vitamin E suppresses the elevation of the plasma CTC concentration due to ACTH in chickens, possibly by inhibiting the conversion of CHOL ester to free CHOL in the adrenal gland.”

“Feed efficiency was lowered by CTC treatment, while this was significantly (p < 0.05) minimized by feeding the vitamin E diet.”

“Pretreatment of the rats with DZ or VE diminished the stress-induced increases in plasma corticosterone and glucose levels and reversed the decrease due to stress on brain ATP, glucose, glycogen and pyruvate contents.”

“ACTH response to stress is similar in all groups, whereas the corticosterone response is higher in the animals treated with alpha-tocopherol.”