Possible Interaction: Corticosterone and Tryptophan

“Hypothalamic corticotropin releasing hormone mRNA levels were lower and plasma corticosterone levels tended to be lower in the animals that received implicated L-TRP.”

“In rats we showed that a diet of low tryptophan resulted in higher stress responses and higher corticosterone production.”

“The secretory pattern of corticosterone can be modulated by increasing the Trp content of the diet, possibly as a result of reciprocal interactions between the serotonergic system and the hypothalamic-pituitary-adrenal axis.”

“Repeated injections of corticosterone (5 mg/kg daily) in fact induced a rise of brain tryptophan hydroxylase levels in neonatal brain.”

“Also, L-Trp causes to decline increased serum corticosterone level under heat stress and fasted state.”

“ L-tryptophan had a significant reducing effect on the serum corticosterone level in the fasted state in comparison with the fed state, and also revealed a significant decline at the dose of 25 mg/kg BW on the elevated serum corticosterone under heat stress.”

“A total of 28 metabolites were identified as biomarkers for ovariectomized-…, LysoPC(15:0), l-carnitine, glucose, arginine, citric acid, corticosterone, …, tryptophan , arachidonic acid, Cer(d18:0/18:0), glutamine, uric acid, 8-HETE, estriol, which … glutamate metabolism, arginine and proline metabolism, citrate cycle (TCA cycle), and arginine biosynthesis.”