Possible Interaction: Corticosterone and St John's Wort

“ResultsThe anxiety/depressive-like … due to chronic corticosterone treatment was reversed by exogenous administration of Hypericum perforatum ; the proliferation of progenitor cells in mice hippocampus was significantly reduced under chronic corticosterone treatment, whereas a long term treatment with Hypericum perforatum prevented the corticosterone-induced decrease in hippocampal cell proliferation.”

“ Corticosterone levels were significantly (P<0.01) decreased by 52 and 58 percent by citalopram and St John's Wort respectively.”

“Results show that HP significantly reduced corticosterone and cortisol in brain frontal cortex tissue.”

“Studies have suggested that HP might alter brain cortisol and corticosterone through its effect on multidrug transporter glycoprotein (Pgp).”

“Daily treatment with either imipramine, Hypericum extract or hypericin alone or in combination with procyanidin B2 for 14 days significantly decreased plasma ACTH and corticosterone levels.”

“Further, the observed attenuating effect of HP on TNF-α and corticosterone could contribute in its antidepressant effect in this animal model by other ways than their effects on tryptophan-kynurenine metabolism pathway.”