Possible Interaction: Corticosterone and Progesterone

“ Progesterone exposure reduces play-fighting in male rats, as does corticosterone.”

“ Progesterone also binds significantly to the receptors with an affinity varying between 16% and 41% of the corresponding affinity of corticosterone in different species.”

“The addition of progesterone (4 microgram/ml) to the medium caused increased production of cortisol and corticosterone , but had no effect on DHA production.”

“Results Progesterone and corticosterone concentrations were strongly correlated (ρ = 0.74; P < .001).”

“Overall, these results suggest that although CORT is likely to be the primary stress-related hormone responsible for constraining cytokine expression evoked by stress, CORT and PROG may exert certain combined actions that temper stress-induced neuroinflammation.”

“When CORT and PROG were co-administered, a small effect on expression of the decoy receptor, IL-1R2 was observed, suggestive of an anti-inflammatory response.”

“When plasma levels of ACTH, CORT, and progesterone were analyzed across studies, CORT and progesterone were found to be highly correlated and rarely dissociated.”

“In addition, progesterone treatment decreased serum corticosterone compared to the controls and sham.”

“ Progesterone treatment decreased TBI induced anxiety and serum corticosterone levels, and increased serum IGF-1 levels.”

“Further, normal display of lordosis by rats treated with corticosterone + progesterone in contrast to its absence in corticosterone alone treated rats suggests that impaired progesterone secretion due to action of corticosterone leads to inhibition of lordosis.”

“Areas under the cortisol and corticosterone curves calculated for 30 min period after the OT injection were statistically higher (p<0.05) during the luteal than the follicular phase.”

“Correlation analysis indicated that there is a significant relationship between plasma levels of progesterone and corticosterone and the quality of nests built by the dams.”