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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Corticosterone
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“N-3 PUFA decreased blood levels of adrenocorticotropic hormone and corticosterone , and brain expressions of corticotropin-releasing factor and miRNA-218, which increased the expression of the glucocorticoid receptor.”
N-3 PUFA improved post-menopausal depression induced by maternal separation and chronic mild stress through serotonergic pathway in rats - effect associated with lipid mediators.“N-3 PUFA also modulated the hypothalamic-pituitary-adrenal (HPA) axis by decreasing circulating levels of adrenocorticotropic hormone and corticosterone and expression of hypothalamic corticotrophin releasing factor and hippocampal miRNA-218 but increasing the hippocampal expression of glucocorticoid receptor.”
“Our results suggested that the mechanisms underlying these effects are possibly associated with the reduction of corticosterone levels promoted by the PUFAs supplementation in the stress-induced animals.”
“Mixture of polyunsaturated NAEs containing mainly 18:1w9, 18:2w6, 18:3w3, 20:1w9, 22:1w9 increased the labeling of aldosterone by 70% (p < 0.05) and corticosterone by 20% (p < 0.05).”
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