Possible Interaction: Corticosterone and Oxytocin

“These findings underscore that preadolescent exposure to OT can reverse some of the long-lasting effects of postpartum maternal CORT and FLX treatments in the adult offspring.”

“In the adult male rat, the intravenous injection of interleukin-1 beta (IL-1 beta; 0.2–0.3 micrograms/kg), VP (0.3–0.9 micrograms/kg), and OT (30 micrograms/kg) significantly increased plasma ACTH and corticosterone levels.”

“ Oxytocin produced significant increases of the plasmatic corticosterone levels, this effect being stronger and longer lasting after the superior dose.”

“Although there are some indications of CORT influencing OXT neurotransmission, specific effects of CORT on neurohypophyseal or intra-hypothalamic release of OXT have not been studied in detail.”

“In addition, treatment with OXY along with CORT , significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only.”

“Suppression of cell proliferation caused by corticosterone was reverted by oxytocin treatment in which cell proliferation, cell differentiation, and dendritic complexity increased.”

“ Oxytocin and corticosterone ( CORT ) interact to mediate hormonal stress responses and can be altered by cocaine use.”

“Post‐exposure treatment with oxytocin significantly corrected the corticosterone stress response, decreased glucocorticoid receptor expression and increased mineralocorticoid receptor expression in the hippocampus compared to vehicle treatment.”

“ Oxytocin also decreased the number of CRF‐positive cells in the paraventricular nucleus and corticosterone release.”

“ Oxytocin administration significantly attenuated the release of ACTH and corticosterone and the increase in corticotropin-releasing factor mRNA expression in the hypothalamic paraventricular nucleus (PVN) in response to 30 min restraint.”