Possible Interaction: Corticosterone and Melatonin

“Whereas corticosterone potentiates melatonin production, incubation of the gland with tumour necrosis factor‐α decreases pineal hormonal production.”

“In contrast, supplementation with 20 mg/kg MT reversed the elevation of the plasma CORT levels, downregulated the colon ROS levels and inhibited the changes in the intestinal microbiota induced by restraint stress.”

“ Melatonin treatment reduced the corticosterone , 11-DHC, cortisol, cortisone, aldosterone and progesterone in response to T. cruzi infection.”

“It will be interesting to explore other molecular mechanisms for melatonin regulation, albeit increased corticosterone is implicated in the enhanced production of melatonin.”

“RESULTS Me atonin su pplementation suppressed an increase of cor ticosterone le vel and a decrease of melatonin level caused by SD.”

“The crosstalk between adrenal and pineal … under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB. This transcription factor, which modulates the expression of a key enzyme in melatonin synthesis, is sharply reduced at the entrance of darkness in the rat pineal gland.”

“After the last treatment, mice were subjected to restraint stress (RS) for 2 h. MLT markedly decreased serum levels of corticosterone after RS.”

“Moreover, melatonin administration to LPF rats reduced corticosterone and prevented glucose intolerance.”

“ Melatonin also counteracted the effect of Cd on 24-h rhythmicity of circulating PRL, LH, TSH, and corticosterone.”

“ Melatonin significantly phase-delayed expression of Per1, Per2, and Cry1, also phase-delayed the plasma corticosterone circadian rhythm, and increased the amplitude of plasma corticosterone and thyrotropin rhythms.”