Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Corticosterone and Gossypol

supplement:

Gossypol

Research Papers that Mention the Interaction

ACTH-induced corticosterone secretion and intracellular adenosine monophosphate (cAMP) formation were significantly inhibited by gossypol at concentrations of 8.6 and 4.3 microM, respectively, and by gossypolone at concentrations of 8.6 and 4.3 microns, respectively.
Research communications in chemical pathology and pharmacology  •  1991  |  View Paper
A more pronounced inhibitory effect was observed upon 11 beta-hydroxylation of steroids; I50 was 11 microM. Seventy-five percent of corticosterone production was impaired when 30 microM of gossypol were present.
The Journal of Steroid Biochemistry and Molecular Biology  •  1990  |  View Paper