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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Corticosterone
supplement:
Glutathione
Research Papers that Mention the Interaction
“The imaging results showed that the natural compound 3 C3 ) can downregulate GSH levels in HepG2 cells, which was accompanied by reactive oxygen species (ROS) release and apoptosis induction.”
An endogenous Cys-assisted GSH@AgNCs-rGO nanoprobe for real-time monitoring of dynamic change in GSH levels regulated by natural drug.“TPC ranged from 0 to 2 mg/mL could significantly elevate the amounts of reactive oxygen species (ROS) in … of protein (p < 0.05) at 24 h. On the contrary, antioxidant enzymes superoxide dismutase (SOD), glutathione GSH ), and …/mL TPC for 24 h. In addition, … HepG2 cells was impeded.”
“ Corticosterone effect was associated with depletion of reduced glutathione and increase of lipid peroxidation, in addition to modification of biogenic amines; decreased serotonin and dopamine.”
Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines“In rats that were implanted with corticosterone (CORT) or control pellets, CORT caused a significant decrease in muscle glutathione levels and a corresponding increase in protein carbonylation, an irreversible oxidative modification of proteins.”
“ CORT significantly increased SOD activity in the PFC and HC, decreased GSH levels in the HC and increased LP in all brain areas studied when compared to saline-treated animals.”
“4 The strong correlations between corticosterone and oxidative damage markers (e.g. protein oxidation, lipid peroxidation and GSH levels) suggest a relationship between these parameters.”
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