Possible Interaction: Corticosterone and Glucose

“On the basis of the … cytochalasin B, hydrocortisone, prednisolone, corticosterone , and phenolphthalein are considered as … to be competitive inhibitors of D-glucose transport with Ki values of 2.2 x 10(-4) M, 3.0 x ….0 x 10(-4) M, and 2.5 x 10(-5) M, respectively.”

“Plasma glucose GLU ), triglyceride (TG), total cholesterol (TCHO) and CORT contents were increased by CORT administration.”

“Plasma triglycerides, free fatty acids, total ketone bodies, glucose , and glycerol were all significantly increased by corticosterone and the choice diet but inhibited by insulin.”

“Moreover, corticosterone reduced postoperative plasma interleukin-6, catecholamines, and glucose (all P < .001-.05) without any effect on the plasma corticosterone concentration compared with vehicle-treated controls.”

“Lipoprotein lipase activities in either cervical or abdominal adipose tissues, rather than in thigh fat tissue, were significantly elevated by either lucose or c orticosterone treatment.”

“Plasma concentrations of lucose, urate, triglyceride, non-esterified fatty acids (NEFA), very low density lipoprotein and insulin were all significantly increased by c orticosterone treatment.”

“Plasma levels of glucose , urate, and total free amino acids were all significantly decreased by CORT treatment.”

“The plasma levels of glucose , urate and total amino acid were significantly elevated by CORT treatment.”

“Plasma concentrations of glucose and urate were significantly increased by acute CORT administration, whereas the lactic acid was not changed.”

“The protection provided by corticosterone supplementation in TCDD toxicity is more likely due to reduced peripheral utilization of glucose enabling the animals to maintain marginal normoglycemia.”

“Levels of aldosterone were decreased but those of corticosterone increased in the perfusate from arteries treated with glucose.”