Possible Interaction: Corticosterone and Gamma-Aminobutyric Acid

“Results showed that pretreatment with bicuculline enhanced both LPS- and IL-1-induced corticosterone secretion; while pretreatment with GABA significantly reduced the LPS-stimulated corticosterone release (p<0.05, vs LPS alone).”

“Bath application of corticosterone (100 nm) to prefrontal cortical slices suppressed GABA release onto principal neurons in layer V of the prelimbic region, when examined 1 h later, which was prevented by application of a CB1 receptor antagonist.”

“Our results indicate that GABA acts in the PVN to inhibit stress-induced corticosterone secretion via both its receptor subtypes, especially GABA-B. In contrast, GABA in the PVN stimulates oxytocin secretion through GABA-B receptors and does not alter prolactin secretion.”

“The acute administration of corticosterone (20 mg/kg) produced an expected increase in hippocampal concentration of extracellular glutamate and a smaller but significant enhancement of local concentration of GABA.”

“Only in young rats did the administration of corticosterone (1 mg/kg, 30 min) reduced GABA levels in the corpus striatum (34%).”

“The effects of DHPG were long lasting with substantial elevations in corticosterone remaining … a similar manner, the group III mGlu receptor agonists, L‐AP4 4‐phosphono‐2‐aminobutyric acid ) and L‐SOP (… to increase serum corticosterone levels at 1 h. In contrast, the … LY354740 (10 mg/kg, i.p.)”

“These results demonstrate that CORT administration is associated with a complex regulation of mRNA expression for pre‐ and postnatal aspects of the hippocampal GABA system.”

“Furthermore, we found that CORT treatment decreased the negative modulation of hippocampal [35S]TBPS binding by both GABA and THDOC and increased the enhancement of [3H]flunitrazepam binding by GABA and THDOC in the dentate gyrus.”

“The administration of gamma-aminobutyric acid (GABA) in the brain right lateral ventricle reduces serum corticosterone levels, and induces significant variations of hypothalamus biogenic amines in conscious male rats.”

“In the latter case, CT also reduced the inhibitory effect of gamma-aminobutyric acid on PS and enhanced the excitatory action of the opioid peptide D-Ala2-D-Leu5-enkephalin.”