Possible Interaction: Corticosterone and Epinephrine

“All three c mpounds o ffered protection against epinephrine-cyclopropane arrhythmias, markedly raising the threshold to injected ep inephrine. ”

“At the suborganismal level, corticosterone treatment decreased relative adrenal , liver, and triceps surae muscle mass, as well as tail length, but increased both subdermal and reproductive fat pad masses, as well as hematocrit.”

“ConclusionsThe present findings indicate that corticosterone and epinephrine cooperate to facilitate behavioral responsiveness to cocaine.”

“Further, although no change was observed in the expression of POMC mRNA, adrenal activity (as judged by the changes in total cholesterol, 3beta HSD, cortical cord width and cortico-medullary ratio) exhibited suppression or stimulation following treatment with corticosterone or metapyrone, respectively.”

“Exogenous corticosterone decreased preoperative plasma adrenaline but did not change plasma glucose or insulin levels.”

“ Corticosterone and epinephrine , only when administered in combination, over five days, produced a qualitatively similar effect as sound stress, i.e. bradykinin‐induced plasma extravasation was significantly decreased in males and increased in females.”

“The same high dose of corticosterone given to adrenal‐intact rats also increased behavioural reactivity.”

“Both saline and adrenaline caused more significant increases in corticosterone levels in female rats than in male ones.”

“reduced plasma CST levels while not significantly affecting EPI.”

“The present results suggest that corticosterone treatment can abolish the centrally evoked vasodepressor responses to close to maximal doses of adrenaline and neuropeptide Y, which may contribute to their hypertensive properties in man.”