Possible Interaction: Corticosterone and Dehydroepiandrosterone

“Coadministration of DHEA completely reversed the neurodegenerative effects of chronic corticosterone treatment.”

“In HVC, DHEA is neuroprotective and counteracts several pronounced effects of corticosterone.”

“In an efferent target of HVC, the robust nucleus of the arcopallium (RA), DHEA increased RA volume, but this effect was blocked by coadministration of corticosterone.”

“We have previously shown that DHEA attenuates cocaine‐seeking behaviour, and also that DHEA decreases corticosterone (CORT) levels in plasma and the prefrontal cortex.”

“ Dehydroepiandrosterone (DHEA) has been implicated to have many anti-stress properties with the potential to mitigate some of the actions of corticosterone.”

“In particular, corticosterone (CORT) and dehydroepiandrosterone (DHEA) can have opposing effects, where CORT reduces while DHEA increases neurogenesis and neuron recruitment.”

“ DHEA significantly reduced corticosterone levels for infected and stressed animals with DHEA.”

“The …) DHEA inhibited AngII-, high concentration of KCl-, …-, 25-OH-cholesterol-, pregnenolone-, progesterone-, deoxycorticosterone-, corticosterone- , A23187-, or CPA-stimulated aldosterone release; (2) DHEA increased 25-OH-cholesterol-stimulated pregnenolone release but not …-cholesterol was combined with trilostane; (3) DHEA noncompetitively inhibited aldosterone synthase but showed uncompetitive inhibition of P450scc.”

“Although opposing actions of DHEA and corticosterone have been proposed in a rat model, the effects and action mechanisms of DHEA on rat adrenal zona fasciculata-reticularis (ZFR) cells are still unclear.”

“…)DHEA inhibited ACTH-, 8-Br-…-, progesterone- or deoxycorticosterone-stimulated corticosterone release; (2) DHEA increased 25-OH-cholesterol-stimulated pregnenolone release but not when 25-OH-cholesterol was combined with trilostane; (… of 11β-hydroxylase but not P450scc; (4) DHEA affected the expression levels of StAR protein but not of P450scc.”

“ Corticosterone reduced the number of cells labelled with a marker for neurons (NeuN) following a 28‐day survival period, and this was also prevented by DHEA.”

“Treating adult male rats with subcutaneous pellets of dehydroepiandrosterone (DHEA) increased the number of newly formed cells in the dentate gyrus of the hippocampus, and also antagonized the suppressive of corticosterone (40 mg/kg body weight daily for 5 days).”

“We report here that the steroid dehydroepiandrosterone protects neurons of primary hippocampal cultures against the toxic effects of corticosterone.”

“However when the corticosterone and the anti-glucocorticoid (AED or DHEA ) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha.”