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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Corticosterone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Serum corticosterone concentrations remained significantly elevated for approximately 60 min after ACTH stimulation.”
“The cranes receiving ACTH increased their serum corticosterone concentrations as much as fivefold above baseline concentrations.”
SERUM CORTICOSTERONE RESPONSE TO ADRENOCORTICOTROPIC HORMONE STIMULATION IN FLORIDA SANDHILL CRANES“Moreover, the release of ACTH binds the receptor MC2-R and stimulates the generation of glucocorticoids such as corticosterone and cortisol, which interact with the transcription factors AP-1 and NF-kB. In skin keratinocytes, ACTH promotes the generation of pro-inflammatory cytokines, which enhances T-cell activity.”
“The exposure to 100 nM corticosterone for 60 min inhibited the CRH-induced ACTH release.”
“Infusion of corticosterone intracerebroventricularly into adrenalectomized rats increases basal ACTH , tends to increase CRF, and allows facilitation of ACTH responses to repeated restraint.”
“As expected, ACTH (10(-8) M) raised corticosterone secretion and lowered proliferation rate of cultured cells.”
“When PEPCK-IGF-II transgenic mice were subjected to an ACTH challenge, corticosterone levels were stimulated 6-fold, to 396 +/- 17 ng/ml after 60 min, compared with 230 +/- 24 ng/ml in the control group.”
“By direct and indirect connections VP serves to inhibit corticosterone secretion, not only by affecting ACTH secretion but also by controlling the adrenal cortex via a neuronal route.”
“Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice.”
Alterations in the Pituitary–Adrenal Axis of Adult Mice Following Neonatal Exposure to Interleukin-1“After injection of ACTH , adrenal cortisol and corticosterone concentrations were stimulated by almost 40- and threefold, respectively, whereas the content of C-21 steroid precursors, namely pregnenolone, 17-hydroxypregnenolone, progesterone, and 17-hydroxyprogesterone, was stimulated by two- to 10-fold.”
“In plasma, ACTH had a marked effect on corticosterone , cortisol, and 11 beta-DIONE.”
“Inhibition of ACTH secretion by ion channel blockers or corticosterone has potent inhibitory effects on percentages of CRH-bound cells.”
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