Possible Interaction: Corticorelin Ovine and Adrenocorticotropic Hormone

“Patients showed attenuated net integrated ACTH responses to oCRH (128.0 +/- 26.4 vs. 225.4 +/- 34.5 pmol/L.min, P less than 0.04).”

“In 5 healthy … subjects, o-CRF , 1 microgram/kg … bolus, increased plasma ACTH levels from less than 10 pg/ml to 40.4 +/- 11.0 (mean +/- SD) after 30-60 min, … plasma cortisol from 12.8 +/- 2.8 micrograms/dl to 23.6 +/- 3.1 after 45-60 min.”

“On the other hand, 10(-8) and 10(-7) M of o-CRF significantly stimulated ACTH release in cultured bronchial carcinoid cells.”

“ Ovine CRF (21 nmol) significantly (P>0·01) stimulated ACTH release from all tumours.”

“The association of ACTH response with CSF concentration of AVP and the dose of oCRF followed second-order kinetics.”

“… oCRH administration … of ACTH and cortisol was observed in every patient tested (ACTH peak 83.81 +/- 28.49 in HD vs. 78.73 +/- 22.87 pg/mL …; cortisol peak 30.73 +/- 19.31 in HD vs. 20.05 +/- 3.19 micrograms/dL in controls).(ABSTRACT TRUNCATED AT 250 WORDS)”

“There was, however, a blunted ACTH response to oCRH.”

“In all patients with Cushing's disease, ovine corticotropin-releasing factor , given intravenously as a bolus injection (1 microgram per kilogram of body weight), caused a further increase in the already elevated levels of ACTH and cortisol.”

“At 1 min post-treatment, bCRH + VP, VP and bCRH increased ACTH secretion by 22.4-, 9.6- and 2.2-fold, respectively, relative to Control (32.7 +/- 7.2 pg/ml).”

“injections with 50 micrograms ovine corticotropin releasing factor oCRF ) significantly increased adrenocorticotropin (ACTH; P < or = 0.01), cortisol (CORT; P < or = 0.004), and progesterone (P < or = 0.036), but not beta-endorphin (P > or = 0.52).”