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“Under lysosomal conditions, the Zn(II) complexes were shown to transmetallate with copper ions , leading to redox-active copper complexes that induced lysosomal membrane permeabilization (LMP) and cytotoxicity.”
Journal of medicinal chemistry • 2016 | View Paper
“In the presence of an optimal concentration of copper (0.5 microM in the present assay system), an inhibition was observed upon addition of Hg(II), Zn(II ), or Ni(II).”