Possible Interaction: Copper and Vitamin E

“ Vitamin E and melatonin can prevent the majority of metal-mediated (iron, copper , cadmium) damage both in vitro systems and in metal-loaded animals.”

“Also, significant positive correlations were observed between intakes of vitamin E and copper with catalase enzyme activity [R = 0.22 and R = 0.21 respectively] (P < 0.05).”

“Examination of the time course of Cu2+ reduction in tocopherol enriched and depleted LDL indicates that tocopherol may determine Cu reduction at early time points but that the eventual capacity of LDL to reduce Cu may depend on more complex interactions between tocopherol and other LDL components.”

“In addition, a complete depletion of lipoprotein vitamin E was observed with CS, whereas copper decreased vitamin E levels by approximately 50% in each fraction.”

“The chicks that received supplemental of vitamin E exhibited significantly higher serum concentrations of Zn (P < 0.05) and significantly lower concentrations of Cu , glucose, and uric acid (P < 0.05) when exposed to heat stress.”

“In the presence of copper , the alpha-tocopherol and most phenolic compounds significantly inhibited the formation of AAS and GGS.”

“Both melatonin and vitamin E also inhibited rises of lipid peroxidation and hydroxyl radical generation and prevented the inhibition of Cu ,Zn‐superoxide dismutase in the hypertrophic heart.”

“Pretreatment with the reactive oxygen scavengers aspirin or vitamin E provides partial protection against copper toxicity and reduces inducible transcription.”

“Co-incubation with N-acetyl-serotonin or vitamin E significantly suppressed the copper (I)-induced malondialdehyde production (p<0.0001).”

“Supplementation with Cu increased liver concentrations of Cu and alphatocopherol.”