Possible Interaction: Copper and Vitamin A

“The updated DVs may lead to … with respect to 8 vitamins vitamin A , thiamin, riboflavin, niacin, vitamin … minerals (zinc, selenium, copper , chromium, molybdenum, and chloride), and have mixed effects on 2 vitamins where the amount …) (natural vitamin E compared with synthetic vitamin E and folic acid compared with folate).”

“Interactions between Cu and vitamin A affected levels of Cu in liver and kidney, while Fe and Zn in kidney were affected by interactions between Cu and Zn.”

“Two-way interactions between Cu and vitamin A affected liver retinyl palmitate and the sum of liver retinol+retinyl palmitate.”

“Inverse relationships between copper and vitamin A liver concentrations have been suggested.”

“It is suggest that vitamin A influences metabolism of Cu , Fe and Zn possibly, in part, due to a decrease in secretion of transport proteins by the liver.”

“A further instance can therefore be added to the series of inverse relationships already knonm to apply between Cu and retinol.”

“ Cu supplementation increased the level of vitamin A in liver, possibly on account of the effect of CuSO/sub 4/ in eradicating intestinal parasites. (”

“Choline and high concentrations of Cu and Zn significantly increased VA , VK3, VB1, and VB2 loss during storage (p<0.05).”