Possible Interaction: Copper and Vanadium

“Spectacular influence of vanadium action was observed on copper and zinc level in examined tissue.”

“The underlying mechanism of the interaction of copper and vanadium is not known, but it does not lie in changes in feed consumption or organ burdens of vanadium, as represented by the femur vanadium concentrations.”

“ Vanadium administration throughout the study reduced relative liver weight (RLW), nodular incidence (57.15%), total number, and multiplicity (48.45%) with restoration of hepatic zinc (Zn), magnesium (Mg), selenium (Se), copper (Cu), iron (Fe), and calcium (Ca) contents when compared to the carcinogen control.”

“Supplementation of vanadium normalizes the level of zinc, iron, and copper as revealed by proton-induced X-ray emission analysis to a substantial extent (P < 0.01).”

“The mechanisms by which vanadium exerts its toxic effects are poorly understood, but interference with the normal kinetics and macromolecular binding of the body's other essential metals, such as Zn, Ca, Mg, Fe, Cu may play a significant role.”