Possible Interaction: Copper and Tryptophan

“It is concluded that dietary TRP is capable to increase common carp tolerance to copper toxicity via mitigating copper-induced stress rather than restoring gill dysfunction and hydromineral imbalance.”

“The copper-dioxygen complex at the active site additionally stabilizes the molecule, and removing of the copper ions increases the tryptophan emission and the quantum yield of the fluorescence.”

“In addition, the chelation of tryptophan with copper ions increased the coordination binding energy, which showed that α-configured Amadori compounds were readily able to form multi-ligands copper complexes.”

“Taking Cu as the indicative element emitted from e-waste recycling activities, significant high positive correlations between Cu and W , and Cu and Te were found.”

“It was a consequent chelation of copper ions that caused the quenching of tryptophan residue.”

“The results from the response surface curve suggested that there was interaction between tryptophan and copper in a way that might resulted in positive effect on laccase production from Crinipellis sp. RCK‐1.”

“The fluorescence emission spectra revealed that pH and copper (II) might exert different effects on the microenvironment of Trp residue and thereby on the protein conformation, which could be further verified by UV-visible and Raman spectra.”

“High concentrations of Trp (over 50 μmol/L) strongly prevented ascorbate oxidation by copper , and therefore inhibited the production of HO(•) needed for Trp oxidation.”

“The large drop in the percentage Trp oxidation at higher concentrations may be due to the chelation of copper by Trp.”

“The intensities of the 2E transition of tyrosine and the phosphorescence of both tyrosine and tryptophan are substantially reduced when the copper is oxidized.”

“This suggests that even traces of copper or other heavy metals might influence the stability of tryptophan.”