Possible Interaction: Copper and Trientine

“ Trientine caused the Cu balance to become negative in diabetic subjects through elevated urinary Cu losses and suppressed elevated EC-SOD.”

“The key strategy of treatment is to reduce the amount of copper in the liver and other tissues by administering both copper-chelating agents, such as D-penicillamine or Trientine , and/or zinc acetate.”

“The mainstay of initial therapy is Cu-chelators like D-Penicillamine, and Trientine for reduction in body copper to sub-toxic levels.”

“ TETA treatment significantly increased the content of Cu in the hypertrophied myocardium, decreased type III collagen deposition and reduced cardiac fibrosis.”

“… copper plus … of tetA , while decreasing both the prevalence and gene copies of tetB. In summary, tet gene presence was initially very diverse in the gut bacterial … differentially impacted the prevalence and quantity of the various tetracycline, ceftiofur and copper resistance genes resulting in a less diverse gene population.”

“ Copper supplementation reduced the teratogenicity of TETA ; the reduction was correlated with an increase in maternal and fetal tissue copper levels.”

“ Copper supplementation by a lower dose of TETA suppresses pressure overload-induced cardiac hypertrophy.”

“However, the incubation of copper with TRIEN or EDTA (but not histidine) prior to GSH addition, totally prevented the loss of the original GSH-bleaching capacity.”