Possible Interaction: Copper and Tetracycline

“A structural equation modeling analysis indicated that Al, Cu , and Zn could significantly aggravate accumulation of tetracycline antibiotics in the soil, whereas there were only significantly direct paths from Cu to ciprofloxacin and norfloxacin.”

“However, extended feeding of 125 mg/kg Cu throughout the finishing period seems to decrease enterococcal susceptability to tetracycline , tylosin, and quinupristin/dalfopristin.”

“Results also demonstrated that an environment co-contaminated with relatively high sublethal concentrations of copper ion and tetracycline co-contaminated environment could induce much higher antibiotic resistance than the low sublethal and control groups.”

“The study proved that a copper ions and tetracycline co-contaminated environment could considerably enhance the mutation frequencies of chloramphenicol and polymyxin B resistance in antibiotic susceptible E. coli ; however, the equivalent copper ions and tetracycline alone showed weaker effects.”

“However, the existence of Cu can decrease the adsorption effect of tetracycline by TWBC700.”

“Indeed, the impregnated Cu species in the siliceous frameworks of MSNs establish pH-responsive coordination interactions with the guest molecules, tetracycline (TET), which not only enhance their loading efficiency but also assist in their release in the acidic environment precisely.”

“Results: Some effects were seen for all biocides, but the largest effects were observed with copper in combination with the antibiotic tetracycline.”

“Thermodynamics parameters ΔG0 for TC were more negative in the TC plus Cu than the TC-only treatments, indicating the spontaneity of TC adsorption increased with increasing of Cu concentrations.”

“The maximum adsorption capacity and adsorption affinity constant of copper ions decrease from 1856.06 to 1486.20 mmol kg(-1) and from 1.80 to 1.68 L mmol(-1) in the absence and the presence of tetracycline.”

“The maximum adsorption capacity and the adsorption affinity constant for tetracycline dramatically increase from 53.82 to 93.04 mmol kg(-1) and from 1.22 to 10.20 L mmol(-1) as the copper concentration is increased from 0 to 0.5 mmol L(-1).”

“The presence of tetracycline decreases the copper adsorption, which may be ascribed to the competition of tetracycline with copper ions for the adsorption sites at the chitosan surface.”

“The presence of copper significantly improves the tetracycline adsorption likely due to the formation of cationic bridging of copper between tetracycline and chitosan.”

“The uptake of copper increases with an increase in pH from around 3.5-6.0 in the absence and the presence of tetracycline.”

“Thus, the protective action of ascorbate + tetracycline as well as the rate of autoxidation of ascorbate in this mixture were enhanced by 0.1 micron Cu , and these effects were counteracted by pyrophosphate probably through chelation of iron that contaminates phosphate.”