Possible Interaction: Copper and Serotonin

“We have previously shown that serotonin induces oxidative cleavage of DNA strands in the presence of copper ions.”

“ Cu inhibited 5-HT uptake into human platelets when platelets were separated from plasma (the IC50 0.7-0.8 microM).”

“Divalent copper Cu ) and methyl mercury (Met-Hg) are potent inhibitors of the uptake of 5-hydroxytryptamine (5-HT) in rat hypothalamic synaptosomes in vitro.”

“Secondly, the inhibition of 5-HT uptake by Cu appears to be purely plasma membrane related but Met-Hg may, in addition, induce release of 5-HT from storage granules.”

“ Copper reduced the 5-HT and VIP induced secretion to a larger extent than zinc.”

“An interaction between copper and serotonin has been suggested by symptoms observed in a number of neurodegenerative diseases such as Wilson’s and Prion diseases.”

“These results indicate that copper structurally alters serotonin and this process may play a role in copper related neurodegenerative diseases.”

“Using PC12 cells as a model of neuronal cells, we show that the interaction between copper and serotonin is toxic to undifferentiated cells.”

“The fact that copper induced a rapid and massive release of 5-HT from the eyestalk can explain its demonstrated role in inducing the release of cHH and the consequent hyperglycemia in intact but not eyestalkless animals.”

“Combined exposure of Mn and Cu also produced a greater elevation in the levels of dopamine (DA) and norepinephrine (NE) and a depression of 5-hydroxytryptamine (5-HT) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet.”