Possible Interaction: Copper and Selenium

“Furthermore, Se increased Cu and Zn absorption, and enhanced MT generation, and improved GPX, CAT, and SOD antioxidant activity, and decreased MDA concentrations and lipid peroxidation levels, all antagonistic to Cd, Pb and Cr.”

“ Selenium had synergistic effects on Zn and Cu in rabbitfish.”

“However, over the years, numerous elements such as As, Cu , Zn, Cd, Hg, Sn, Pb, Ni, Co, Sb, Bi, Ag, Au, and Mo have been found to inhibit anti-carcinogenic effects of selenium , which may affect the anti-carcinogenic activity of selenium.”

“Magnesium and selenium supplementation of diets resulted in increased apparent fecal losses of copper while no effect of manganese supplementation was found.”

“For the first time-to our knowledge-we showed that the uptake of Hg, Cd, and Cu by rice could be inhibited by the presence of Se in the soil.”

“The interaction between Pb and Cu decreased TNF-&agr; levels and so did the interaction between Cd and Se.”

“Colocalisation of Cu and Se in these cells (Weekley et al. in J. Am.”

“Mercury, selenium and copper levels were within exposure ranges reported among similar populations, whereas the distribution of lead … than prior reports; only one infant had a cord blood lead above 10 μg/dL. Levels of selenium were significantly correlated with concentrations …'s ρ=0.20) and copper (Spearman'….51).”

“Selenium K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy revealed Se-Se and Se-S bonding, but not Se-Cu bonding, despite the spatial association of Se and Cu.”

“The accumulation of Se was associated with a greater than 2-fold increase in Cu , which was colocalized with Se.”

“Concentrations of Zn and Cu were significantly higher and the concentration of Se was lower in these patients.”

“Also, there were a significant negative correlation between serum levels of Cu and Se in the preeclamptic women (r = -0.407, P < 0.05).”